100% purity methylene blue powder 100g 3.5 oz pharmaceutical grade aquaculture

Description

[zipedit]
Methylene Blue
Pharmaceutical grade
100% purity
SINCE FEBRUARY 2021 METHYLENE IS PACKED IN SPECIAL SEALED BAG. IF YOU WANT A PRODUCT IN HDPE BOX, PLEASE WRITE TO US BEFORE PURCHASE
DESCRIPTION
100 gram (3.52 oz) nett weight
100% purity, no impurities, no heavy metals
Using 100 grams you can prepare 10 litres (338 fl oz) of 1% methylene blue solution, which is the most often used in medicine, biology, aquaculture and considered as safe. Beware of making stronger solutions.
ANTI AGING
A cheap dye that is normally used to treat cyanide poisoning could hold the key to the ‘fountain of youth’, scientists say.
Methylene blue, a powerful antioxidant, has turned back the clock on the skin of people in their 80s – offering hope of an anti-wrinkle treatment ‘for all ages’.
The dye has been used in medicine for more than 140 years for a variety of things – from staining bodily tissue during surgery to killing bacteria in urinary tract infections.
It works by destroying disease-causing free radicals. Recently it’s shown promise in fighting Alzheimer’s disease.
And now scientists at the University of Maryland have found another use: anti-ageing.    Lead author Professor Zheng-Mei Xiong said: ‘Methylene blue demonstrates a great potential to delay skin ageing for all ages.’
The researchers tested it for four weeks in skin cells from healthy middle-aged donors and octogenarians as well as patients diagnosed with progeria – a rare genetic disease that ages them quickly.
Methylene blue – first synthesized in 1876 – out-performed three other antioxidants N-Acetyl-L-Cysteine (NAC), MitoQ and MitoTEMPO (mTEM).
Fibroblasts – skin cells that produce the structural protein collagen – experienced a decrease in damaging reactive oxygen species, a reduced rate of death and an increase in the rate of cell division throughout the treatment.
Anything that helps maintain collagen levels in the skin will keep it looking younger as natural levels of start to fall in your mid-30s.
By the age of 55 they may have fallen by 40 percent. Less collagen means skin that sags and wrinkles.
Prof Kan Cao said: ‘Our work suggests methylene blue could be a powerful antioxidant for use in skin care products.
‘The effects we are seeing are not temporary. Methylene blue appears to make fundamental, long-term changes to skin cells.’
Antioxidants help counteract the effects of free radicals – unstable molecules in our body’s cells which help speed up the ageing process
BRAIN, MEMORY AND OTHER THINGS
Methylene Blue boosts brain health and function in several ways. But two in particular stand out.
Methylene Blue improves
memory
.
Unlike other nootropics which often work by increasing
neurotransmitter
synthesis and
neural
signaling, MB improves memory by increasing brain cell respiration. Or how the brain cell utilizes oxygen.
Studies show dramatic increases of cellular oxygen consumption and glucose uptake when using Methylene Blue. MB increases
CMRO
2
(cerebral metabolic rate)
through increased activity in the mitochondrial
electron transport chain
.
Methylene Blue functions as an
alternative electron carrier
in the
electron transport chain
in mitochondria. It accepts electrons from
NADH
and transfers them to
cytochrome c
.
[iv]
Cytochrome complex (cytochrome c)
is a component of the electron transport chain in
mitochondria
. Playing a role in
apoptosis
and as an antioxidant.
Methylene Blue also stimulates glucose metabolism. Taken together, increases in
CMRO
2
and
glucose uptake
means that
MB elevates oxygen consumption which helps glucose increase
ATP
production
.
Increases in ATP production provides more cellular energy for better overall brain function including
cognition
, mood and memory.
Methylene Blue is an antioxidant.
MB has a unique mechanism of action that is fundamentally different from traditional antioxidants. During cellular respiration, the first
free radical
formed inside a cell is
superoxide (O
2
)
.
Methylene Blue binds to
superoxide
and reduces it to water. It
stops the
oxidative
cascade at its very beginning. Before it gets a chance to do damage
.
[v]
So think of Methylene Blue as having a unique dual property. First, it increases cellular energy production which normally leads to oxidative stress. And second, it
eliminates this oxidative stress
. Making it a
metabolic enhancer and an antioxidant
.
Researchers tested Methylene Blue in animal models of neurological disease. First, researchers used rotenone (a potent pesticide) which causes severe
dopamine
depletion in the part of the brain associated with Parkinson’s.
Methylene Blue rescued brain cell mitochondria from the damaging effects of this toxin
. By donating electrons in the electron transport chain broken by rotenone. Essentially
bypassing the broken transport chain with donated electrons as an alternative electron carrier
.
Methylene Blue also countered
cerebral ischemia reperfusion
damage. The tissue damage caused when blood supply returns to tissue after a lack of oxygen. As can occur with
Traumatic Brain Injury
. MB accomplished this by
rerouting mitochondrial electron transfer
.
This means that Methylene Blue dramatically countered the behavioral, neurochemical, and neuropathological impairment found in Parkinson’s disease.
[vi]
How things go bad
As we live life, our brain chemistry and metabolism changes.
↓ Mitochondrial energy levels decline
↓ Attention, memory and mental agility decline
↓ Tau proteins and
amyloid plaques
clog the brain
↓
Free radicals
damage brain cell mitochondria
↓
Cerebral blood flow
declines
All of these changes can happen at any age. And are a product of the food we eat, what we drink, lifestyle habits, the air we breathe and more.
So Methylene Blue can help for
age-related cognitive decline
, as well as a student looking to do better in school. By boosting brain cell mitochondria energy levels. And improving cerebral blood flow.
Methylene Blue to the rescue
Low dose Methylene Blue supplementation provides memory enhancing effects in animals and humans. It works as an antidepressant, is anti-aging, helps dementia, Huntington’s and Alzheimer’s.
Methylene Blue increases low blood pressure, improves
cognition
in healthy people, boosts mitochondrial function, is anti-microbial, can eliminate fear and even slow skin aging.
Methylene Blue boosts acetylcholine
Research shows that
Methylene Blue
is an
acetylcholinesterase
inhibitor with a preference for muscarinic acetylcholine
receptors
. Meaning MB prevents the breakdown of
acetylcholine
and making more available in your brain.
[vii]
Methylene Blue is an antidepressant
Methylene Blue is a
monoamine oxidase inhibitor (MAOI)
. It inhibits MAO-A more than MAO-B, but inhibits both at large doses.
[viii]
One study in 1987 showed that 15 mg per day of
Methylene Blue was a potent antidepressant in those with severe depression
.
[ix]
Another study with 31 bipolar disorder patients compared 300 mg per day of Methylene Blue with 15 mg per day. The patients were also on
lithium treatment
. The study showed that the 300 mg dose of Methylene Blue was a “
useful addition to lithium in the long-term treatment of manic-depressive psychosis
”. And patients were significantly less depressed.
[x]
Methylene Blue resists Alzheimer’s Disease
Alzheimer’s disease and other forms of dementia are associated with a buildup of the protein
Tau
. Clinical trials show that
Methylene Blue inhibits Tau formation
. And is under consideration as a treatment for Alzheimer’s.
[xi]
Methylene Blue has an inhibitory action on the cGMP pathway, and affects other molecular events closely related to the progression of Alzheimer’s.
Methylene Blue boosts
neuron
resistance to the formation of
amyloid plaques
and
neurofibrillary
tangles
. And helps
repair impairments in mitochondrial function and cellular metabolism
.
Research also shows that
cholinergic
,
serotonergic
and
glutamatergic
systems all play important roles in the development of Alzheimer’s and other cognitive disorders. Methylene Blue provides beneficial effects in mediating these pathways.
[xii]
This is particularly significant because most existing treatments for Alzheimer’s can only prevent the disease
before it is diagnosed
. But
Methylene Blue shows promise in delaying the effects of Alzheimer’s and dementia
after
it is diagnosed
.
Methylene Blue is anti-aging
Research shows that
Methylene Blue is an effective anti-aging nootropic
. MB increases
mitochondrial complex IV
by 30%, enhances cellular oxygen consumption by 37-70%, increases
heme synthesis
, and reverses
premature senescence
caused by H
2
O
2
or cadmium.
Methylene Blue is considered a
redox agent
. Meaning it cycles between oxidized and reduced forms. This cycling by
MB helps block oxidant production in brain cell mitochondria
.
[xiii]
Mitochondrial complex IV
is the last enzyme in the respiratory
electron transport chain
of mitochondria. The last step in synthesizing
ATP
. Your cellular and mitochondrial source of energy.
Iron (heme)
is an essential element and participates in oxygen transport,
DNA
synthesis and electron transport
.
Heme synthesis
begins in mitochondria. Every cell requires heme to function properly.
[xiv]
Senescence
or
biological agin
g is the gradual deterioration of cellular function. And is caused by telomere shortening that triggers DNA damage in response to reactive oxygen species, hydrogen peroxide (H
2
O
2
), cadmium and other toxins. Methylene Blue helps prevent
premature senescence
or premature cell death.
Methylene Blue improves memory
Animal studies have shown that
a single low dose of Methylene Blue enhances
long-term contextual memory
. This type of memory is the conscious recall of the source and circumstances of a specific memory.
Other studies show that Methylene Blue in low doses taken
after
the event helps memory retention of the event. A study done with rats revealed why this works.
In this study, rats received 1 mg/kg of MB
post
-training for 3 days. The researchers then measured cytochrome c oxidation in participants brains. The idea was to determine if an increase in metabolic energy was behind the memory enhancing qualities of MB.
The study found that
in the Methylene Blue treated group, brain cytochrome oxidase activity was 70% higher than in the placebo-treated group
.
The findings suggest that
repeated post-training supplementation of Methylene Blue improves memory consolidation
. And this memory boost is due to the increased metabolic capacity in brain regions that require more energy during discrimination learning.
[xv]
The Research
Research into
Methylene Blue
for its therapeutic value goes back to the late 1800’s. But it’s only in the last couple of decades that scientists have been able to decode exactly how Methylene Blue works in the brain. All the way down to the molecular level in
mitochondria
.
A study in 2017 found that Alzheimer’s Disease could be caused by more than the accumulation of
amyloid beta
in the brain. The scientists looked into the two main components that produce energy in cells.
Glycolysis is the mechanism used to convert glucose into fuel for consumption by mitochondria.
Burning this fuel in mitochondria uses oxygen in a process called mitochondrial respiration.
The researchers found that
as the brain ages, mitochondrial metabolism deteriorates
. Resulting in a reduction in the molecules needed for energy production. And possibly the main culprit behind many neurological diseases including Alzheimer’s and Parkinson’s.
[xvi]
A study conducted at Children’s Hospital Oakland Research Institute may have found the solution to this mitochondrial energy problem in brain cells.
The researchers found that
Methylene Blue can prevent or slow the decline of mitochondrial function
.
One of the key aspects of Alzheimer’s is mitochondrial dysfunction. Specifically complex IV dysfunction. And this is where Methylene Blue steps in.
The study found that
Methylene Blue enhances complex IV in mitochondria. It increases oxygen consumption. And it reverses premature cell death
.
The researchers concluded that
Methylene Blue may be useful to delay mitochondrial dysfunction with aging and the decrease in complex IV in Alzheimer’s disease
.
[xvii]
Methylene Blue Improves Memory
26 healthy volunteers aged 22 – 62 participated in a double-blind, randomized, placebo-controlled clinical trial. Purpose of the study was to measure the effects of
Methylene Blue on working memory and sustained attention
.
Study results showed that
a single low-dose of Methylene Blue resulted in an increase in
short-term memory
ability. In an area of the brain associated with the senses and visual processing.
Timothy Duong, Ph.D., the study author concluded
Methylene Blue showed promise “in healthy aging, cognitive impairment, dementia and other conditions that might benefit from drug-induced memory enhancement”
.
[xviii]
Another study published in the
American Journal of Psychiatry
tested fear extinction (elimination of fear) and contextual memory. Both are forms of
long-term memory
.
In this study, participants received either Methylene Blue or a placebo
after
being placed in a small dark chamber for a couple of minutes to address their fear.
One month later,
participants that had used Methylene Blue had less retained fear
than those given a placebo. The study authors concluded, “
Methylene Blue enhances memory and the retention of fear extinction
”.
[xix]
Methylene Blue helps Bipolar Disorder
Increasing evidence shows that
bipolar disorder
may be a progressive condition. Dealing with bipolar symptoms long-term results in deterioration of the
cortex
and less
gray matter
.
A study at Dalhousie University in Halifax compared the effectiveness of lamotrigine (Lamictal
®
) along with daily supplementation of either 195 mg or 15 mg of Methylene Blue in patients with bipolar disorder.
Patients took a dose (Lamictal and either 195 mg or 15 mg of Methylene Blue) for three months. Then switched to the other dose for 3 months. The team found that
bipolar participants had reduced depression and anxiety when taking the higher dose of Methylene Blue
compared to when they were on the lower dose.
Several bipolar disorder patients in the study chose to continue using Methylene Blue after the study concluded
.
[xx]
Dosage Notes
Recommended
safe doses based on clinical studies with animals and humans
ranges from 0.5 – 4 mg/kg. So a 90 kg (200 lb.) body weight translates to 45 – 360 mg of Methylene Blue.
45 mg of Methylene Blue is a safe starting dose. But 360 mg of MB is much too high in my opinion even if you’re 200 lbs.
The bottom line is there is no true recommended dose for Methylene Blue. My recommendation is start with the lowest dose of 0.5 mg/kg and see how you react.
Methylene Blue is
water-soluble
so you don’t need to take it with a meal, or healthy fat like some nootropics.
Methylene Blue has a half-life of about 5 hours. So you can dose twice a day.
Methylene Blue is famous for turning urine blue. But for most neurohackers, your urine will only stain blue at doses roughly exceeding 500 mcg. Some recommend preventing blue urine by mixing Methylene Blue with ascorbic acid for 3 hours before taking it.
Methylene Blue is also available as a doctor-administered injection for therapeutic use. Typically used to treat diseases like malaria or with anti-cancer therapy.
Side Effects
Methylene Blue shows a hormetic dose-response, with opposite effects at low and high doses.
In other words, lower doses of Methylene Blue work well as a nootropic. But high doses do not because MB can potentially “steal” electrons away from the
electron transport chain
. Disrupting the redox balance and acting as a pro-oxidant (instead of an antioxidant).
[xxi]
Adverse effects of Methylene Blue also come from chemical impurity.
Even pharmaceutical (USP) grade Methylene Blue can contain impurities like arsenic, aluminum, cadmium, mercury and lead
.
At low doses, these contaminants are not that big of a problem. But higher doses will result in the accumulation of these toxins in your cells.
Side effects with Methylene Blue are rare
when doses are under 2 mg/kg. But can include stomach pain, chest pain, dizziness, headache, sweating, confusion, high blood pressure, shortness of breath, accelerated heartbeat, tremor, skin turning blue, urine turning blue or green, reduction of red blood cells, or jaundice (only reported in infants).
Monoamine Oxidase (MAOI) inhibition
becomes a big problem at around 2 mg/kg of Methylene Blue. So if you are using antidepressants or antianxiety medications that affect
serotonin
, you should NOT use Methylene Blue. Because using Methylene Blue with one of these medications could cause
Serotonin Syndrome
.
This includes SSRI’s and MAOI’s such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, zimelidine, bupropion, buspirone, clomipramine, mirtazapine and venlafaxine.
Do not use Methylene Blue if you are pregnant or breast-feeding.
Available Forms
Methylene Blue
is sold as a liquid, and in crystalline powder form.
Industrial-grade
and
chemical-grade
Methylene Blue is sold as a dye or stain. And can consist of more than 8% – 11% of various contaminants. And should NOT be used as a nootropic.
Only
pharmaceutical (USP) grade Methylene Blue
should be used as a nootropic. Ask for a
Certificate of Analysis
which should include the amount of contaminants such as arsenic, aluminum, cadmium, mercury and lead.
Nootropics Expert Recommendation
Methylene Blue 0.5 – 4 mg/kg of body weight per day
We recommend using Methylene Blue as a
nootropic
supplement.
Your body
does not
make Methylene Blue on its own. So to get its benefits you must take it as a supplement.
Methylene Blue is especially helpful for those dealing with anxiety and depression.
Methylene Blue is also particularly useful to students and executives who want to boost
cognition
, learning and
memory
.
Methylene Blue is a fast-acting nootropic that can also help prevent brain
mitochondrial
degeneration. Providing potential as an anti-aging nootropic.
Methylene Blue donates electrons in the electron transport chain in your mitochondria. So experienced neurohackers suggest avoiding
CoQ-10
or
idebenone
when using MB because it seems to make Methylene Blue much less effective.
Idebenone
is an Alzheimer’s drug that has some nootropic benefit. But it works similar to Methylene Blue because it acts as a transporter in the electron transport chain of mitochondria. Competing with Methylene Blue.
Sources:
https://nootropicsexpert.com/methylene-blue/
https://skin-challenges.com/news/methylene-blue-reduced-wrinkles-and-slowed-skin-ageing-for-women-in-their-80s-study-reveals/
IMPORTANT INFO
Because of covid, delivery time can be longer.
Delivery to the USA/Canada usually takes 7-20 days, there is no duty fees.
Delivery to the UK 5-7 days, Germany 10 days, to the Europe takes up to 20 days.  Delivery worldwide is vary.
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